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Have you, or your lab, considered getting an electronic lab notebook? Are you not sure if the ELN will be good for your lab? Do you have lots of ELN questions? You're not alone.
Research scientists all over the world are making the switch from using old-fashioned lab notebooks to adopting a modern electronic lab notebook. And for good reason.
ELNs are powerful technologies, so there are multiple factors to consider. This article will help you understand the benefits of moving your lab notes into a digital environment to help you accelerate the pace of your scientific discoveries.
What is an Electronic Laboratory Notebook? An Electronic Laboratory Notebook (or ELN) is exactly what it sounds like - it's a digital version of the traditional lab notebook. It's a place where you can record and store your experimental results.
Unlike a traditional notebook, an ELN allows you to access, share, and analyze data in a way that is not possible with a paper lab book. Instead of just being words on a page, an ELN is a sophisticated software platform that allows you to aggregate important information about your experiments into one digital place, making it easily searchable and reusable for subsequent experiments.
Since the vast majority of research data is digital to begin with, the ELN makes printing out and then cutting and pasting results into a paper notebook obsolete. The ELN also spells the end of illegible handwriting or damaged notebook pages that make reading past experimental results or procedures impossible. The ELN is making manual notebook use obsolete entirely - and for good reasons.
At the same time, ELN differs from general-purpose note-taking software, such as Evernote and Microsoft OneNote, because the former is custom-built for scientific research. Whether you need to draw a chemical structure or document a bioassay protocol, you can bet that an ELN will have those capabilities.
Even if your lab already has its procedures in digital form, where are they stored? Are they secure? Who can access it? Does your whole team have access to the key documents they need or are things in disparate places on individual computers? These are essential questions that protect the integrity of your work, your lab, and your intellectual property.
An ELN provides the ability to have your procedures, your raw data library, and your analyzed results all in one secure place. While the ELN market offers a variety of choices, it's important to evaluate the quality of those ELNs and to decide if the ELN meets the needs of your lab. There are important questions to consider. For example, is it a collaborative ELN for working with colleagues with complementary expertise? Is it directly integrated with my database? Is it easy to get started?
The paper laboratory notebook has been around for centuries. Scientific breakthroughs from the 18th Century through to today have at one point been recorded in such a notebook. Writing in a notebook can feel like you are connecting with some of history's science greats. In the words of Isaac Newton, "If I have seen further than others, it is because I stand on the shoulders of giants." And while nostalgia is great, it is not the best way to do high-quality science. Today, we have better tools for tracking research and better tools to (re)-use our past results.
One massive problem facing today's science is reproducibility. When experiments are not reproducible, everyone suffers - from wasting time pursuing a result that was not real to creating products that end up not working. It's a huge and important issue. Multiple factors feed into the reproducibility crisis, but correctly recording and documenting experimental procedures and results is key to improving reproducibility.
Additionally, not creating digital records of data accounts for 17% of data loss and is a major cause of delays and setbacks in research. With an ELN, your experimental data becomes searchable and all the results are at your fingertips. It's like being able to do a ctrl-F on your old-fashioned notebook. You can also conveniently do a ctrl-C or ctrl-V.
The ELN platform records procedures and data much more reliably and thoroughly than is possible with traditional notebook entries. All changes are stored in the software and because the raw data can be stored alongside the analyzed results, it's simple to see how a conclusion was drawn.
While the paper laboratory notebook has been around since the dawn of scientific study, this does not mean that we should just keep using it. The technical advancements of the past 50 years or so have increased the complexity of research experiments tremendously. The methods that we use to record, store, and share our data need to match these technical advancements.
In today's world, the majority of research data capture, analysis, and results are performed and presented in a digital format. Having to transcribe your digital data onto the written page and then back into a digital format for publishing is unnecessary, time-consuming, and prone to errors. If you want your research to move forward at the rapid pace of science in the Internet era, using an ELN is non-negotiable.
An ELN should work with underlying data generation, archival, and mining capabilities. Ideally, these technologies support natural workflows for your scientific research. Commonly used data analysis software can be integrated directly with an ELN so that all the parts of your experiment can be stored in one place. This allows a complete view of all experiment records, data analyses, and protocols.
You can see a step-by-step view of the experiment and all the modifications and analysis that have been done. Using an ELN provides transparency within your research group, allowing your pace of discovery to accelerate.
Given today's digital and global culture, it is ironic that lab notes sometimes can be one of the last pieces of the research process that have resisted modernization. Digital platforms have streamlined and optimized much of today's scientific research and development. Because data and protocols are digital, they are most useful in software for automated computational processes tools. The key is to automate the more manual aspects of digital workflows, whenever practical.
Scientists work in labs where lab equipment is controlled by computers for data acquisition and analysis. There is a need for secure and reliable documentation of both the data and protocols (also sometimes referred to as metadata). Leading companies and academic labs have embraced the digital paradigm. Science has always been data-driven. Today, it is driven by much more data than in the past.
Pen and ink notes have been revered as a sacred pillar of history that scientists trust and respect. Its sense of simplicity and reliability and inertia has caused them to resist this piece of modernization. The ritual of handwritten tracking methods and sharing their recorded information is the old way of recording experiments. With electronic laboratory (learning) notebooks, scientists can enter, store, and share their data as appropriate. The technology provides greater security, accuracy, and reproducibility of the work.
Moving into an electronic laboratory notebook allows for more organized, legible data combined with superior record-keeping. Significant time savings come from searchability and the integrity of data. Can't remember what laboratory instruments you used in that experiment five years ago? A quick search gives you the answer, rather than having to flip through volumes of pages.
The benefits of the ELN go beyond just making lab note-taking work digital. ELNs are high-functioning data managers that can incorporate data from multiple sources. Regardless of the data source, the ELN provides a permanent archive and an audit trail.
Data and protocols from your phone, your computer, or manually entry can be imported in standardized formats in an ELN. Standard file formats allow you to separate the data from the applications. Ideally, a web-based lab notebook app interface provides easy access and increased accuracy for a variety of different projects, labs, and collaborations within a single system.
Say goodbye to messy pages and scribbled, illegible writing. Now your data is stored in a centralized system that manages the entire research continuum.
Benefits of an Electronic Lab Notebook include:
There is always a small risk of a security breach with any system, even with data encryption assurances. Most security breaches are functions of suboptimal user behavior (i.e., avoiding best practices). However, increased monitoring, security "defense in depth", awareness of best practices, and vigilance can significantly minimize security risks. More information on how you can help maintain the security and privacy of your data can be found online.
There are pros and cons of hosted versus on-premise ELNs, but clearly the trend has been to much greater adoption of hosted solutions due to a number of advantages (economic, scale, collaborative, rate of improvement, convenience of deployment, uptime, security, etc.).
Using an electronic laboratory notebook can be nearly as easy as using popular word documentation software. Digital software programs have made the move to digital notebook an easy transition with a much lower learning curve than in the past.
Instead of documenting your notes, processes, and research protocol in a notebook made of writing paper, those same notes will be entered or imported through a centralized computer system. Ideally, you access your electronic lab notebook from any internet-connected device - whether you are logged in from a computer, phone, tablet, or another mobile device.
The ELN data notebook entry process through a text editor provides formatting you would find in a Word document. With online notebook systems with a user-friendly interface, you can simply try the system to see how easily it will work. ELNs allow for seamless importing and exporting of documents and spreadsheets. More specialized scientific ELNs can analyze specialized lab data types like chemical structures, biological sequences, dose-response curves, annotations, and controlled vocabularies.
You'll have formatting capabilities and the ability to organize your documents easily. A collaborative ELN allows researchers to either keep content private or selectively share it with an entire team. Whether done individually or collaboratively, powerful searching technologies allow for different ways to interrogate the content and different data types. Searching through all the documents with appropriate access permissions balances privacy with group efficiency.
The digital notebooks incorporate and organize graphs, images, tables, and annotations. You can create SOPs and templates to assist with reproducibility. The available features of an ELN ideally can be accessed through an intuitive user interface within a software platform that is nearly as easy to use as familiar office-based or online document-sharing packages.
When performing experiments, your notebook is a legal document that represents your scientific results. When filing for patents, or making related intellectual property claims, the lab book becomes formal evidence. As scientists, you are aware of the importance of your lab notes and your scientific work. A traditional notebook is not necessarily the best way to maintain an accurate and thorough record of your experiments.
Lab notes are often kept secure by being locked up in the lab overnight. This works, but it means that the notebook is inaccessible anywhere except in the lab during the daytime.
What about your data and results? How are those being stored? Many researchers are using online databases like Dropbox or Google Drive integration to share and store their data. And while this is convenient, it does not provide the same level of access control as an ELN.
A more secure way to share among lab members and collaborators is an electronic research notebook. The ELN platform provides secure software that can house both your research data and corresponding protocols on the electronic record.
The FDA has also switched to encouraging organizations to submit completely electronic documents, as traditional methods are becoming obsolete. Back in 1997, the FDA deemed that electronic records would hold up legally in the same way as handwritten records. This opened up the gates for the adoption of electronic research notebooks.
However, to ensure the security of research data, the FDA implemented even more stringent guidelines for the ELN. In what is commonly referred to as 21CFR11 and GxP, the FDA upped the standards that medical and pharmaceutical companies had to meet to rigorously document their processes for using digital data security.
Typically documented functionality includes processes using electronic signatures, audit trails, modification tracking, and thorough standard operating procedures (SOPs) throughout the organization. These requirements are more important at the later stages of drug discovery and development, the closer you get to an Investigational New Drug (IND) filing.
Rigorously documenting your processes using an ELN will help your organization stay compliant, and maintain data integrity, and data security.
Where your ELN lives can address many needs for security and shareability. The primary concern for this valuable data lies in protecting it and making it accessible to the right people at the right time. Ideally, the technology works so well that it is just taken for granted.
ELNs can be hosted or within an organization's on premise environment.
With a hosted server - the most popular storage option, there are advantages that include:
The downside to hosted solutions from a third-party provider include:
For some research organizations, a hosted solution is preferred, and for others, an on-premise environment is preferred. A middle option is a private cloud server. Your ELN software provider should be familiar with the pros and cons of the different options. Ideally, there is expertise and documentation of best practices.
Ease of setup, use, and reduced costs are prevailing decision-making factors for an organization adopting hosted solutions. For larger companies with different data storage and backup policies, the additional costs of an on-premise solution may be worth it.
One of the biggest benefits of using an ELN is that you can easily share your data and results with lab members and collaborators, in a controlled manner. You can choose who can see what scientific data, who can edit or add to the ELN, and who has admin access. Instead of emailing important results or sharing spreadsheets in Google Drive, you can securely and quickly share your research with the people who need access to it. An ELN together with a registration system can be a complete data management solution.
Allowing for real-time collaboration between researchers saves time and money. Researchers don't have to wait around for the data they need to perform their experiments - or worse, repeat experiments that have already been done, wasting both time and resources.
This is especially useful as collaborations become global and you may not be working in the same location as those people with whom you are collaborating.
Since collaborative research ELN platforms can be hosted solutions, all your data is recorded, stored in a scientific data repository, and can be accessed from anywhere. Experimental results can be instantly shared with the interested parties and the scientific discovery process can continue without a hitch. This is not at all possible with traditional laboratory notebooks. And collaboration is often not practical with on-premise solutions that require cumbersome access methods.
Drug discovery requires an interdisciplinary team. Often, the lack of communication between different teams can cause delays and errors in the pipeline. Using an ELN that all team members can access brings ease, quickness, and confidence into the highly collaborative drug discovery process.
Research is a collaborative effort. So while ensuring the best security protocols are in place to protect your data, you also want to streamline the sharing process to the trusted people on your team and experts in the field. When funding is on a deadline and efficiency equals money gained or lost, the accessibility to data to enhance collaboration is a premium need.
The ELN offers the ability to manage a team by creating access groups and subgroups with flexible restrictions and access functions that open the door to the right data at the right time, to the right people. It allows for exclusivity and the power of selection based on assigned user rights. The specificity of information, how it is accessed, shared and exported can all be controlled. The right platform will also allow you to change team access individually and by group without losing the contributed data.
A team engaged through the ELN can experience increased engagement. Both individuals and organizations can track ownership of their data and appreciate their contributions to the bigger project. Active communication and visual tracking of work creates experiential integration of concrete executed work. The ease of finding and sharing data across the lab creates cohesiveness and enhanced purpose for the lab as a whole.
Some ELN software systems have their own inventory tracking system integration that allows for lab inventory management within the same software that stores your data. Having this feature included in your electronic notebook solution adds benefits from streamlined workflows. There is a significant efficiency when you eliminate the bulk of multiple systems. This powerful capability accessed through the same interface as your data adds extra value from lab management. Ideally, the software supports custom templates and fields to identify and track material information in your database a variety of entities (i.e., protocols, raw bioactivity data points, process data, chemicals, biologicals, drug candidates, antibodies, reagents, primers, plasmids, etc.).
An inventory setup allows you to upload and update quantities of scientific laboratory supplies, expiration dates, lab storage locations, item descriptions, and even scanned barcodes. Again, ideally, you can allow or restrict access to individuals and selected groups.
Good inventory management allows you to easily find specific items and materials used in any particular experiment and reference them, which helps with reproducibility and regulatory compliance.
Regulatory compliance is crucial for organizations in many healthcare data-related industries. The OECD has established Good Laboratory Practices (GLP) guidance for data security and storage that applies to ELNs.
When researching an ELN, you want an assessment of the security measures for data security and storage. You want clear assurance that your data is protected from hackers. You want to track for edits to ensure integrity.
You want restrictions that can be customized and a secure method to share, export, or migrate your data to the right people at the right time. Anyone on your team or with your collaborators may have the key discovery and data that provides the foundation for the composition of matter and/or utility patents.
Your digital lab notebook should provide procedures for exporting and reliability for access and sharing. This will include information on data protection and online backup data storage scheduling.
GLP compliance includes ensuring confidentiality through user agreements, encryption, authentication protocols, and electronic signatures across all levels of your team.
Your ELN can meet strict adherence to GLP best practices - including processes outlined in the FDA 21 CFT Part11 and ISO certification. The right software will give you clarity, data backup, tracking, and clear data paths.
With ELNs coming out in the late 1990s (but still not widely adopted) and Laboratory Information Management Systems (LIMS) coming out in the late 1960s, the longevity of this technology is becoming more widely used in both research and commercial labs today. LIMS has 30 years on the ELN and has seen a dramatic evolution in data management. LIMS's ability to link information from samples and projects has increased their use in QA/QC environments in particular.
While some may consider LIMS and ELN competing systems, they can, in fact, complement each other and provide comprehensive data management for the lab. The lines are becoming blurred as vendors and users use LIMS, ELNs and registration systems to support similar workflows.
LIMS is a database that manages lab resources. Historically LIMS were used to manage information that was then entered into traditional non-electronic lab notebooks. Whereas the ELN manages projects, protocols, data entry, teams, sharing, exporting, publishing, procedures, and team collaboration. An ELN tracks and gives timelines over the process where LIMS manages the research resources including samples, reagents, stocks including order/reorder functionality.
A hearty ELN will include LIMS integration because of the complementary - not competitive nature of the resources it manages. This integration eliminates the redundancy of moving from electronic management to manual systems and back again.
LIMS have been powerful in managing R&D information in a structured database. This can place limits on functionality and usefulness, particularly when dealing with unstructured data from early-stage R&D work coming from multiple sources. ELNs are advantageous in early-stage development because of their features, where data is securely stored, accessed, and selectively shared. Modern systems can handle both unstructured and structured data in an integrated single software platform.
While LIMS have gained mainstream popularity, ELNs have only begun to ramp up in use over the past few years with rapid growth continuing, sometimes one department and lab at a time, and other times across entire organizations.
The use of both ELNs and LIMS has made labs more environmentally friendly and efficient through laboratory automation. ELNs are poised with this integrative workflow to be the final holding space for information and are appealing to labs looking for patent and commercialization of their research. Ease of access and searchability make ELNs in particular a robust data management tool. When ELNs are combined with a strong LIMS (or registration) foundation, together they can provide labs with strong integration tools for competitive growth. The marriage of ELN flexibility and LIMS structure supports many stages of R&D data management with a full range of functions that can evolve and scale with the needs of an organization over time.
Collaborative software platforms blend the best of both systems to offer a full informatics solution tailored to your needs.
There are clear benefits to moving to an ELN. The benefits include improved data documentation, secure and shareable stored data, comprehensive workflow support, role assignments, import/export features, and greater reproducibility. These benefits directly translate to time and money saving. The efficiency and reproducibility improvements are a boon to science… By now you are likely convinced that ELNs have value. Yet choosing one that is right for you and your lab is a process in itself. It's a question not of ELN versus science lab notebook paper, but of which ELN is right for you?
The ELN market is expanding and each has features, price points, support, and adoption curves that may make some better or worse for your particular situation. The landscape can be confusing which is one reason why labs have been slower to adopt ELNs than perhaps you would have expected. Rather than getting stuck in endless feature comparisons, it's a good idea to start out by identifying the non-negotiable "must have" requirements for your particular situation, then seek out the ELNs that fit your needs.
Research scientists are primed for the solution. They are drowning in the volume of complex data that historically was just cut and pasted into lab paper notebooks from multiple sources. Imagine searching across and trying to decipher thousands of those pages from day to day - with penmanship that might make any hope of collaboration impossible.
At the very basic level, the ability to search, copy, archive, share, and export is worth the investment plus the learning curve of adoption. Automated templates add another opportunity for greater ROI. Supervisors gain a full spectrum view of process and progress with the right controls needed to run a tight lab, an efficient ship.
Choosing the right ELN requires appreciating its value - to your own work and to that of the entire lab.
The primary return on investment (ROI) for researchers is in time. The time savings translate to significant increases in efficiency and overall increased productivity which impacts financial bottom lines. In addition to time savings, collaborative ELNs provide additional opportunities for new discoveries. To paraphrase a famous scientific quote from Louis Pasteur "chance favors the prepared mind," and with a collaborative ELN "chance favors prepared minds."
ELNs save time in the following areas:
The costs associated with setup and licensing can provide a relatively high value for a low cost for your lab. Consider the TCO (total cost of ownership), including the time investment of learning a new system based on how intuitive it is to use. ELN vendors can help with moving your data over, and onboarding your team.
Overall, these are relatively small investments compared to the ROI of time and money savings for researchers. Researchers have a need to manage data, projects, and inventories and to explore more advanced data mining research functionality.
Many ELNs are customizable to the exact needs of each project and team in ways not even conceivable with handwritten data recording. Real-time updates and administrative efficiency produce additional time savings per lab members of measurable hours (as a function of the number of collaborators).
When added up across a team, the return on investment for time alone is profound and usually compelling. The increased productivity and decreased waste of your lab contribute to the return on investments, which also include lab morale and engaged researchers. The vast majority of researchers who adopt ELNs stay with them long-term, following the one-time set-up.
The modern research and development process is digital. As scientists, you consume and produce data digitally far more often than you do in a paper-based way. It is not possible to excel in a digital world while still using a paper-based notebook to store and record your data—not without wasting precious time in the laborious back-and-forth between digital and physical mediums.
Moving to a paperless lab environment is an inevitable trend in the modern scientific process. The benefits include greater data clarity, collaboration software, compliance, increased reproducibility, decreased waste and time efficiency, improved reporting, reliable storage, convenient data exporting, enhanced lab functionality, and scalable management.
Adding the right ELN solution to your lab brings individual productivity, team synergy, and self-management. ELNs provide a competitive advantage by bringing you to the frontier of research, right where you belong.
If you have questions about ELNs, we're here to help. Below, we have answered a few of the most common questions we hear.
An ELN that supports team collaboration should offer real-time sharing and annotation capabilities, customizable fields for specific project needs, and streamlined data capture that is accessible across team members. CDD Vault’s ELN, for instance, allows users to share insights, annotate entries, and apply business rules that support collaboration and workflow efficiency across disciplines.
Yes, CDD Vault's ELN integrates seamlessly with other tools within its platform, including data visualization, registration, and inventory management modules. This integration allows data to flow efficiently across workflows, minimizing the need for manual transfers and helping teams maintain a single source of truth for project data.
CDD’s ELN includes regulatory-compliant features like audit trails, electronic signatures, and secure data storage, meeting standards such as 21 CFR Part 11 for electronic records. This ensures data integrity and security, which is crucial for labs managing sensitive intellectual property and regulatory audits.
Cloud-based ELNs, such as CDD Vault, generally have lower upfront costs and reduce IT maintenance burdens compared to on-premises solutions. CDD’s platform is fully hosted, which simplifies deployment and reduces operational costs for labs that may lack extensive IT infrastructure.
CDD Vault offers an intuitive interface that new users can learn quickly, often within a few hours with guided onboarding. Additionally, CDD provides ongoing support with a team of lab-trained scientists, making the transition smoother for labs adapting to electronic data management.
Upgrade to CDD Vault’s Electronic Lab Notebook for secure, collaborative, and fully integrated data handling. Contact our team to schedule a personalized demo and see how CDD Vault can support your research goals while protecting your valuable data. Get started today!